Pivotal boost trial protocol pdf

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Pivotal boost trial protocol pdf
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Localised High Risk Prostate Cancer Trial Questions. DIL with a minimum dimension of 5mm. Both T2 and DWI are important and this depends on tumour location in the gland. It was possible to boost DIL toGy to without violating dose constraints inofpatients and to Gy in Trial description: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost Original Protocol Background: The PIVOTALboost trial (ISRCTN) recruits patients with intermediate and high risk, localised prostate cancer; it tests the role of pelvic node PIVOTALboost is a randomised controlled parallelarm phase III multicentre trial in men with localised high and intermediate risk prostate cancer. % atyears. Total DIL volume must be <50% total prostate volume Using spacers significantly reduced rectal dose in allpatients in this study. Table of Contents. Disease free survival. Local recurrence. PIVOTALboost is a multicentre four-arm superiority phase III randomised controlled trial (Fig; full protocol provided as appendix A).Eligible patients are allocated to one of the following treatment arms: A: prostate alone IMRT (control), B: prostate and pelvic IMRT, C: prostate IMRT and prostate boost, D: prostate and pelvic IMRT and prostate boost A scoreorlesion (clinically significant cancer is likely or highly likely to be present) according to the (PI-RADS (v.2) guidelines. At the site of the dominant The PIVOTALboost trial tests two escalation strategies in a high intermediate to high risk groups with locally bulky prostate tumoursAny questions relating to this protocol should be addressed in the first instance to the PIVOTALboost Trial Manager within ICR-CTSU: Email: PIVOTALboost-icrctsu@ General enquiries/ Fax Methods/study design. Consenting patients will be PIVOTALboost Trial Overview. Proactive IV irOn Therapy in haemodiALysis patients (PIVOTAL) PROTOCOL AND STATISTICAL ANALYSIS PLAN.

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