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<p>The scanning electron Abstract and Figures. Biofilm-associated Staphylococcus aureus cells are more resistant to antibiotics and exhibit differences in cell size and growth, gene expression and protein production, compared to their free living counterparts [] Microscopic morphology S. aureus cells are Gram-positive and appear in spherical shape. Microscopic morphology S. aureus cells are Gram-positive and appear in spherical shape. Staphylococcus aureus is a nosocomial bacterium causing different infectious diseases, ranging from skin and soft tissue infections to more serious and life-threatening The purpose of this review is to highlight different aspects of S. aureus biofilm formation and its overall architecture, individual biofilm constituents, clinical implications and role in pathogenesis and drug resistance TLDR. This review comprehensively examines the factors influencing biofilm formation, host immune defence mechanisms, infections caused by biofilms, diagnostic approaches, and biofilm-targeted therapies, which show promising results by improving drug delivery and reducing the side effects The name ‘Staphylococcus’ was derived from Greek, meaning bunch of grapes (staphyle) and berry (kokkos) [1]. Further, it   · Our research has unveiled variations in the buoyant density of free-swimming Staphylococcus aureus cells, irrespective of their growth phase. The yellow  S. aureus forms a complex structure of extracellular polymeric biofilm that provides a fully secured and functional environment for the formation of microcolonies, their sustenance  It includes sixteen chapters that address the microbiology and immunology of S. aureus, the pathology of its key manifestations, and the current standard of care. Cells with a Staphylococcus aureus cells that are encased and protected by biofilms show different phenotypic characters compared to cells in their planktonic form. They are often in clusters resembling bunch of grapes when observed under light  Colony morphology Staphylococcus aureus colonies are characterized by their large, smooth, and elevated appearance with a golden yellow color (2,). They are often in clusters resembling bunch of grapes when observed under light microscope after Gram staining.</p></translate>
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