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<p>Gout is an inflammatory arthritis that occurs in response to the deposition of MSU crystals, the end product of human purine metabolism, in joints, soft tissues, and bones Abstract. More than% of the population in affluent countries has hyperuricemia (21% of males but only 3% of premenopausal females), however, only about % develop gout The genetic, metabolic, and environmental causes of hyperurice-mia and the physicochemical processes that lead to uric acid crystallization have been reviewed in  PATHOGENESIS OF GOUT. In the human body, urate is constantly near its limit of solubility, in a flux balance between production and elimination. URIC ACID PRODUCTION. FIGURELarge, cystic joint erosions producing an overhanging edge (circled area) characteristic of chronic gouty arthritis. Uric acid is formed by breakdown of purines from nucleic acids. TLDR. Urate underexcretion through renal and gut mechanisms is the major mechanism for hyperuricemia in most people Symptoms and signsSuspect gout in people presenting with any of the following: tophiConsider gout in people presenting with rapid onset (often overnight) of severe pain, redness or swelling in joints other than the first MTP joints (for example, midfoot, ankle, knee, hand, wrist, elbow). These lecture notes accompany my lectures on pathophysiology in the study module Pathophysiology. It’s the most common type of inflammatory arthritis. Hyperuricemia is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) crystal formation. By two hydroxylation reactions, xanthine oxidase transforms hypoxanthine FIGURELarge, cystic joint erosions producing an overhanging edge (circled area) characteristic of chronic gouty arthritis. Multiple interacting checkpoints are involved in the pathophysiology of gout. It’s more common  PATHOPHYSIOLOGY OF GOUT. PATHOGENESIS OF GOUT. Arno Helmberg. Published Medicine. key point is that low-grade inflammation persists and crystals remain in the joint, which can lead to progres-sive disease Gout is an inflammatory reaction to monosodium urate crystals. key point is that  What is gout? Gout is a painful form of arthritis caused by uric acid crystals that form in and around the joints.</p></translate>
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