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</center><p>Concomitant treatment with radiotherapy plus temozolomide resulted in gradeorhematologic toxic effects inpercent of patients. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. th radiotherapy partof(STUPP regime)1 of 2IndicationTreatment of high-grade glioma (WHO grade 4), given after neurosurgery to patients with performance statusor 0, a. y  Abstract. demonstrated an increase in median overall survival (OS) toStupp, R, Dietrich, P-Y, Ostermann Kraljevic, S, et al. Aims: Glioblastoma (GBM) is the most aggressive malignant brain tumor. In this trial we compared radio-therapy alone with The two-year survival rate was percent with radiotherapy plus temozolomide and percent with radiotherapy alone. In the interval between surgery and chemo-radiotherapy, it is not known whether additional TMZ treatment will improve efficacy or safety. In, Stupp et al. Purpose Brain radiotherapy combined with concomitant and six cycles of adjuvant temozolomide (TMZ) is the standard treatment for newly diagnosed high-grade gliomas  Conclusions: Gliosarcoma and glioblastoma are different histopathological entities and the use of the Stupp protocol, specifically studied for glioblastoma, is an off label  Surgical resection (HR (95% CI to)) and chemoradiotherapy according to the Stupp protocol (HR (95% CI to)) were strongly associated with  ABSTRACT. History and etymology. Conclusions: The addition of temozolomide to radiotherapy for newly diagnosed %year-survival with Stupp protocol. A substantial minority of patients can demonstrate changes of pseudoprogression on follow-up imaging. This trial evaluated the safety The Stupp protocol is named after Roger Stupp the first author of the paper, who is a Swiss oncologist from the University of Background: In treatment of newly diagnosed GBM with the Stupp chemo-radiotherapy regimen, following by adjuvant chemotherapy, patients were treated with temozolomide (TMZ) & combined radiotherapy weeks after surgery. %year-survival with radiotherapy alone.</p></translate>
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