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</center><p>Here, the very presence of these complexes, in addition to the PMNs attracted by complement Gell and Coombs were the first to categorize hypersensitivity reactions intotypes according to pathophysiology, but more recent insights into. the mechanisms of these disorders have since modified the original classification system. This review describes the immune mechanisms involved in each of the modern Gell-Coombs categories Department of Pathology, Room L, Farmington Avenue, Farmington, CT, USA. Gell and Coombs classified hypersensitivity reactions into four ‘types’. I suggest that the premise that these reactions represent ‘hypersensitivity’ manifestations is limiting and that they represent four major strategies that the body uses to In this chapter, emphasis has been placed on the core mechanisms underlying the broad categories of hypersensitivity responses distinguished on the basis of the Gell and Coombs classification and based on differences in the immune reactants (antibodies or cells), the form of the presented antigen, and the effector mechanisms involved In the Gell–Coombs system, Type III hypersensitivity reactions occur when antibody reactions occur in the blood, resulting in the formation of antigen–antibody complexes, which are deposited in the glomerular and/or pulmonary basement membranes. I suggest that the premise that these reactions represent ‘hypersensitivity’ manifestations is limiting and  In this chapter, emphasis has been placed on the core mechanisms underlying the broad categories of hypersensitivity responses distinguished on the basis of the Gell and  TLDR. Classic and less classic examples of the original criteria for hypersensitivity reactions are reviewed, where current disease pathophysiology does not always fit the  The original Gell and Coomb’s classification categorizes hypersensitivity reactions into four subtypes according to the type of immune response and the effector mechanism scribe an excessive and/or pathogenic immune response to either foreign or self antigens. In the Gell-Coombs system, hypersensitivity is roughly classified into four types, and they are briefly described as follows: (1) Type I; IgE antibody-mediated anaphylaxis against  Gell and Coombs classified hypersensitivity reactions into four ‘types’. This rev Gell and Coombs were the first to categorize hypersensitivity reactions intotypes according to pathophysiology, but more recent insights into the mechanisms of these disorders have since modified the original classification system.</p></translate>
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